Modelling of skin permeation. Part 1. Polymeric membranes
Jacek Arct 1/, Barbara Cetner-Nowakowska 2/
1/ Dr Seidel Foundation, Warsaw
2/ Faculty of Chemistry, Warsaw Technical University
The processes of skin penetration and the importance of barriers used in research on this process are described. The synthetic barriers used in various types of research are briefly characterized in separate sections. The numerous experiments carried show that the obtained results, in general, cannot be correlated with those obtained for human skin in vivo or in vitro. Comparative studies of various synthetic membranes were carried out using porous synthetic membranes made of cellulose acetate and polyethersulfone, which allowed us to accurately assess the donor system´s influence on the permeation coefficient. In contrast, in the case of continuous membranes such as polydimethylsiloxane or ethyl vinyl acetate, there was an interaction between the donor system and the barrier. It resulted in a change in the diffusion characteristics.
An exception among synthetics is the recently explored Strat M® membrane made of multiple layers of different polymers. This membrane in various comparative studies showed permeability similar to human skin.
Synthetic membranes have several advantages, such as homogeneity or good reproducibility of results. They constitute a significant simplification of the skin structures. Due to possible interactions, they must be carefully selected for the tested chemical compounds and the composition of the transmitting systems used. The influence of the type of membrane used on the obtained results is observed.
Key words: penetration, skin, stratum corneum, modelling, synthetic membrane, diffusion chambers