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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2025, 28(4): 118-125pl  Hydrotropic and micellar solubilization of biologically active substances with poor solubility in water (API). Part I.Marian M. Zgoda 1/, Sławomira Nowak 2/, Zbigniew Marczyński 3/, Piotr Michel 2/ 1/ Zakład Technologii Postaci Leku, Katedra Farmacji Stosowanej Uniwersytetu Medycznego w Łodzi (prof. senior) 2/ Zakład i Katedra Farmakognozji Uniwersytetu Medycznego w Łodzi 3/ Zakład Farmacji Aptecznej, Katedra Farmacji Stosowanej Uniwersytetu Medycznego w Łodzi Summary The principles for selecting surfactants and transdermal penetration enhancers for solid oral dosage forms and preparations administered to the skin and mucous membranes are discussed. In this monography, particular attention is given to the method for calculating predicted intrinsic solubility (the Hildebrand-Scatchard-Fedors theory) and assessing the stability of the micellar adduct formed through the solubilization process. Contemporary methods for calculating the hydrophilic-lipophilic balance (HLB) of surfactants as potential micellar solubilizers of lipophilic drugs and phytochemicals are discussed. Hydrotropic solubilization, the thermodynamic aspects of micellar solubilization, and the method for calculating the micellar partition coefficient are also presented. Contemporary analytical methods for the optimal selection of effective micellar and hydrotropic solubilizers in mass-transfer processes at phase interfaces (transdermal penetration enhancers) are highlighted. Methods enabling the optimal selection of micellar and hydrotropic solubilizers are presented, and the role that solubilization may (and should) play in the stability of dosage forms and, above all, in pharmaceutical and biological availability is discussed. Key words: hydrotropic solubilization, micellar solubilization, solubility, surfactants, pharmaceutical availability |