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Copyright @ Pol J Cosmetol
 
ISSN 1731-0083
Wednesday, 28.09.2022
PL EN
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Pol J Cosmetol 2012, 15(4): 265-271pladd to cart

Rheological parameters and pharmaceutical availability of active substances from glycol arnica extract and morphine hydrochloride from anhydrous absorptive ointments


Grażyna Samczewska, Magdalena Piechota-Urbańska

Zakład Farmacji Stosowanej, Katedra Farmacji Stosowanej UM w Łodzi

Summary
Introduction. Lack in the pharmaceutical market of dermatological products demonstrating simultaneously strong analgesic, anti-inflammatory activity and accelerating wound healing contributed to undertaking attempts to produce ointment with a very strong analgesic acting through opioid receptors - morphine hydrochloride and glycol arnica extract. Anti-inflammatory and accelerating the process of wound healing activity of arnica products is based not only on empirical medicine and on folk medicine but it has been proven in studies on animals and experiments performed in vitro.
Aim. To design prescription for anhydrous absorptive ointments with glycol arnica extract (GAE) and with glycol solution of morphine hydrochloride (GMH), to test their pH, rheological properties and the rate of release of active substances from GAE in formulations with and without morphine hydrochloride (MC).
Material and methods. Four formulations were tested of variable content of white soft paraffin and anhydrous lanolin but of constant content of propylene glycol (vehicle), GAE (batch MA), GMH (batch MCl) and combined GAE and GMH (batch MACl). Extensometric method was used to test the extensibility of the formulations. Potentiometric method was applied to measure pH of the produced ointments. Viscosity parameters were determined with cone-plate digital rheometer. Pharmaceutical availability of active substances from GAE and morphine hydrochloride (MC) was tested by spectrophotometric method.
Results. The per cent content of lanolin affects pharmaceutical availability of active substances found in GAE and in morphine hydrochloride, and it is the highest at 16% content of lanolin in the tested formulations. No effect of CM was observed on the process of the release of substances from GAE, whereas the presence of GAE contributed to the increase of CM pharmaceutical availability.

Key words: anhydrous absorptive ointments, glycol arnica extract, morphine hydrochloride, rheology, pharmaceutical availability