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Copyright @ Pol J Cosmetol
 
ISSN 1731-0083
Friday, 29.03.2024
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Pol J Cosmetol 2020, 23(3): 145-150pladd to cart

Amino acids penetration and permeation through the skin


Magdalena Krulikowska 1/, Jacek Arct 2/, Anna Lembas 3/, Monika Grzybowska 3,4/

1/ Henkel Polska sp. z o.o.
2/ Fundacja dr Seidla w Warszawie
3/ Uczelnia Medyczna im. Marii Skłodowskiej-Curie w Warszawie
4/ Monat Global Poland

Summary
Amino acids are one of the components of natural moisturising factor NMF, due to they have influence on the appearance, lubrication and flexibility of our skin. This compounds appear in ionic form, what makes them soluble in water and have influence on their weak penetration through lipid barrier which is epidermis. In order to check the extent of permeation of amino acids through our skin, the experiments were carried out, both in vivo and in vitro. They demonstrated that amino acids itself, only remotely penetrate through stratum corneum. Also the influence of penetration enhancers and iontophoresis was tested. This study were designed to show how can we increase transdermal penetration of amino acids.

Key words: amino acids, cosmetology, skin, percutaneous penetration, stratum corneum