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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2023, 26(2): 90-97pl  Rofams as potential emulsifiers, solubilizers and transdermal absorption promotersMarian M. Zgoda 1/, Jacek Kosno 2/, Marek Lukosek 2/, Sławomira Nowak 3/, Zbigniew Marczyński 4/, Joanna Gądek-Sobczyńska 5/, Mirosława Świątek 5/, Magdalena Markowicz-Piasecka 4/ 1/ prof. senior, Katedra Farmacji Stosowanej, Zakład Technologii Postaci Leku Uniwersytetu Medycznego w Łodzi 2/ Zakład Procesów Ciśnieniowych, Sieć Badawcza "Łukasiewicz" - ICSO Blachownia w Kędzierzynie Koźlu 3/ Katedra Zakład Farmakognozji Uniwersytetu Medycznego w Łodzi 4/ Katedra Farmacji Stosowanej, Zakład Farmacji Aptecznej Uniwersytetu Medycznego w Łodzi 5/ Katedra Chemii Bioorganicznej i Biokoordynacyjnej Uniwersytetu Medycznego w Łodzi Summary Introduction. The results of research on biodegradable non-ionic surfactants, products of oxyethylation of methyl esters of rapeseed oil acids with the content of oxyethylene segments nTE≤70, confirmed their high solubilizing abilities in relation to cholesterol and lipophilic medicinal agents of BCS class II and III. The physical state of the homologous Rofam series, and above all, the calculated solubility parameter and the solubility level of hydrophile-lipophilic balance. indicates the possibility of using this class of surefactants as a promoter of transdermal passage for non-steroidal anti-inflammatory drugs (NSAIDs). Aim. Calculating the ideal solubility and predictable actual solubility for NSAIDs will make it possible to estimate the impact of the content of oxyethylene segments in the structure of Rofams on the predicted actual solubility in the liquefied structure of diclofenac, ibuprofen, salicylic acid, ketoprofen and naproxen. Material and methods. The topological indices, particle radii and solubility parameter were calculated for NSAIDs and the homologous series of Rofams. The ideal solubility of NSAIDs and their predicted real solubility were estimated in the environment of liquefied Rofam structures. There was investigated the influence of the number of oxyethylated segments nTE in the structure of Rofams on the quantitative course of the solubility of diclofenac, ibuprofen, salicylic acid, ketoprofen and naproxen. Results. There was estimated the predicted real solubility in the liquefied structure of Rofams of nonsteroidal anti-inflammatory drugs: diclofenac, ibuprofen, salicylic acid, ketoprofen and naproxen. The approximation equations were applied to describe the correlation between the content of oxyethylene segments nTE in the homologous series of Rofams and the progression of the predicted real solubility in their liquefied structure. Conclusions. The physicochemical properties of the biodegradable, homologous series of Rofams compatible with human "sebum" enable the preparation of real solutions with the molecular degree of fragmentation of selected NSAIDs, owing to which they can act as a transdermal absorption promoter during the diffusion of the therapeutic agent into the tissue compartment . Key words: Rofams, nonsteroidal anti-inflammatory drugs (NSAIDs), topological indices, ideal solubility, anticipated real solubility |