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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2023, 26(4): 222-229pl  Rapidly disintegrating tablet with dry titrated extract from aloe arborescens (Extr. Aloe arborescens aqu. siccum)Marian M. Zgoda 1/, Zbigniew Marczyński 2/, Ilona Boczek 2/, Wojciech Marcinek 3/, Jerzy Jambor 4/, Agnieszka Szpikowska 5/, Sławomira Nowak 6/, Joanna Gądek-Sobczyńska 7/, Mirosława Świątek 7/, Magdalena Markowicz-Piasecka 2/ 1/ prof. senior, Katedra Farmacji Stosowanej, Zakład Technologii Postaci Leku Uniwersytetu Medycznego w Łodzi 2/ Katedra Farmacji Stosowanej, Zakład Farmacji Aptecznej Uniwersytetu Medycznego w Łodzi 3/ Zakład Produkcji Farmaceutycznej - Aventis Sp. z o.o. w Rzeszowie 4/ Europlant Group Phytopharm Klęka S.A., Klęka 1, Nowe Miasto n.Wartą 5/ Rettenmaier Polska Sp. z o.o. w Warszawie 6/ Katedra i Zakład Farmakognozji Uniwersytetu Medycznego w Łodzi 7/ Katedra Chemii Bioorganicznej i Biokoordynacyjnej Uniwersytetu Medycznego w Łodzi Summary Introduction. Dry titrated extract of aloe arborescens (Ext. Aloe arborescens aqu. siccum) was the inspiration to design and manufacture a model form of the drug - a fast disintegrating tablet. Aim. The aim of the research was to design and manufacture, by direct tableting technique, a solid form of the drug - a fast disintegrating tablet with aloe extract - using in appropriate proportion: Vivapur 112, Vivapur 200, Prosolv SMCC 50 and Prosolv EASY tab. SP. The model drug form should meet pharmacopoeial requirements related to effective disintegration time and high pharmaceutical availability. Material and methods. Applying a technique used in industrial drug form technology, an alternative formulation of fast disintegrating tablets with a dry titrated extract of aloe arborescens was produced. Morphological and pharmacokinetic parameters of the prepared model form of the preparation were determined using pharmacopoeial methods. Results. The availability of phytochemicals from fast disintegrating tablets containing a statistical amount of dry titrated aloe extract was examined using pharmacopoeial methods in model acceptor fluids. The ideal and predicted actual solubility was calculated for barbaloin, aloe-emodin, chrysophanol and aloeresin B and their hydrates which determine the phytotherapeutic profile of the model form of the preparation. Conclusions. A rapidly disintegrating tablet manufactured by direct tableting, containing in specified quantitative ratio titrated extract from aloe arborescens and Prosolv EASY tab. SP meets morphological and pharmacopoeial requirements related to pharmaceutical availability of phytochemicals in model acceptor fluids. Key words: aloe extract, rapidly disintegrating tablet, pharmaceutical availability, ideal solubility, expected actual of phytochemicals |