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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2024, 27(4): 184-193pl  Pharmaceutical availability of phytochemicals from a tablet with a complex erosive disintegration mechanism containing dry ginseng extract (Ext. Panax ginseng siccum)Marian M. Zgoda 1/, Zbigniew Marczyński 2/, Sławomira Nowak 3/, Łukasz Dobrzyński 4/, Piotr Chodak 4/, Katarzyna Kabała 5/, Beata Skibska 2/ 1/ Zakład Technologii Postaci Leku, Katedra Farmacji Stosowanej Uniwersytetu Medycznego w Łodzi (prof. senior) 2/ Zakład Farmacji Aptecznej, Katedra Farmacji Stosowanej Uniwersytetu Medycznego w Łodzi 3/ Katedra i Zakład Farmakognozji, Uniwersytetu Medycznego w Łodzi 4/ Gedeon Richter Polska Sp. z o.o. Grodzisk Mazowiecki 5/ Koło Naukowe przy Zakładzie Farmacji Aptecznej, Katedry Farmacji Stosowanej Uniwersytetu Medycznego w Łodzi Summary Introduction. Manufactured by "Phytopharm Klęka S.A." in accordance with the requirements of the European Medical Agency, the extract from the root of ginseng (Ext. Panax ginseng siccum) containing ginsenosides that effectively solubilize cholesterol was the inspiration to design and manufacture, under industrial technology conditions, an original form of the drug with an erosive release profile of biologically active components. Aim. The structure of the ginseng extract and the granulometrically compatible excipients based on microcrystalline cellulose posed a technological challenge to develop a morphologically stable solid form of the preparation with high pharmaceutical availability using precompression. Material and methods. The technology used in the industrial production of solid forms of preparations was applied to manufacture model, alternative formulations of an ellipsoidal tablet with ginseng extract. The morphological and biopharmaceutical parameters of the model form of the preparation were determined using pharmacopoeial methods. Results. The pharmaceutical availability of phytochemicals from an ellipsoidal preparation containing a statistical amount of dry ginseng root extract was examined in model acceptor fluids. Time-dependent measurements revealed that the crystallographic memory of biopolymers promotes the expansion of the preparation structure, which causes an increase in the surface area and volume of the model tablet. Conclusions. An original form of the preparation containing ginseng extract with morphological parameters that ensure the expected pharmaceutical availability in model acceptor fluids was developed and manufactured using the direct tableting technique under industrial technology conditions. Key words: dry ginseng extract, structure expansion coefficient, pharmaceutical availability |