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Pol J Cosmetol 2024, 27(4): 194-199pl  Mechanisms of action and factors influencing the effectiveness of chemical peels in the context of potential skin reactionsAleksandra Dębczyńska, Elżbieta Rębiś Katedra Nauk Farmaceutycznych, Collegium Medicum, Uniwersytet Jana Kochanowskiego w Kielcach Summary Introduction. Chemoexfoliation is a peel performed using acids. Its action is comprehensive, and indications for the procedure include, among others, symptoms of aging and photoaging, various types of acne and rosacea, and pigmentation changes. The reduction of these mentioned changes is possible thanks to a complex mechanism of action and many factors influencing the effect of exfoliating substances. It is important to note, however, that the procedure of chemoexfoliation may be associated with the occurrence of unpleasant post-treatment reactions. It is worth noting, however, that chemoexfoliation may involve some discomfort. Aim. The aim of the study was to evaluate the frequency of adverse reactions following the chemoexfoliation procedure. Material and method. The study was conducted on a group of 52 women aged between 18 and 50 years. The research tool was an anonymous questionnaire consisting of 23 questions. Results. The vast majority of respondents reported experiencing a burning sensation during acid application. Itching occurred in 23.5% of the participants. The most frequently reported adverse effect was erythema, noted by 19.6% of respondents. Itching was experienced by 9.8%, and swelling by 5.9% of women. The acids most commonly associated with adverse effects were glycolic acid and salicylic acid. Only 5.9% of respondents selected mandelic acid and trichloroacetic acid. Conclusions. A burning sensation is the most commonly reported feeling during the chemoexfoliation procedure. The most frequent adverse reaction after acid treatment is erythema. Glycolic acid and salicylic acid were identified as the acids most frequently responsible for adverse reactions. Key words: chemoexfoliation, chemical peels, acids |