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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2014, 17(2): 103-107pl  Matrikines in skincareJacek Arct, Małgorzata Gulba Wyższa Szkoła Zawodowa Kosmetyki i Pielęgnacji Zdrowia w Warszawie Summary Matrikines are low molecular weight peptides derived from the extracellular matrix proteins, primarily of elastin, collagen, fibronectin and thrombospondin. We divide them into two groups - natural matrikines, occurring in tissue and necessary for its proper functioning and cryptic matrikines (matrikryptins) that arise when interrupting the continuity of tissue (injury), stimulating the cells to the rapid restoration of the structure. Matrikines are similar to other biologically active LMW peptides they differ in origin and active concentration. Several biological matrikines and their active analogues are obtained by synthesis or biotechnological methods, inter alia by hydrolysis of the corresponding proteins. Due to the ability to stimulate the skin tissue renaval they found widespread use in anti-aging cosmetics. Key matrikines have INCI names and respective companies offers them on the market. Use matrikines in cosmetology increases, due to activity, origin and the selectivity of action.Their use is considered to be completely safe. Future matrikines in medicine also looks very promising due to their ability to inhibit the growth of tumor cells. Key words: matrikines, matricryptins, extracellular matrix, elastin, fibronectin, thrombospondin, collagen |