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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2014, 17(4): 323-327pl  Influence of pharmacopeial ointment basis on rheological parameters and pharmaceutical availability of morphine hydrochloride from anhydrous absorptive ointmentsGrażyna Samczewska 1/, Aneta Berner-strzelczyk 2/, Magdalena Piechota-urbańska 1/ 1/ Zakład Farmacji Aptecznej, Katedra Farmacji Stosowanej, Uniwersytet Medyczny w Łodzi 2/ Zakład Technologii Postaci Leku, Katedra Farmacji Stosowanej, Uniwersytet Medyczny w Łodzi Summary Introduction. On the pharmaceutical market there are not available already prepared semi-solid preparations to use on a skin and mucosa, which include in their composition hydrochloride morphine - one of the strongest opioid analgesic. The reason of such situation is basicly caused by the high perishability of mentioned analgesic in the water environment. Previous researches made at KFS of UM in Lodz carried out that the adequate durability has a glycol solution of morphine hydrochloride. Aim. To design a prescription for anhydrous absorptive ointments with morphine hydrochloride (MH), test their pH, rheological properties and the rate of analgesic release through a semipermeable membrane to water. Material and methods. There were tested two series of ointments prepared on the same lipophilic substrate, the first of a series included 10% of propylene glycol, while the second one included 10% glycol solution of morphine hydrochloride which concentration was at level 2.2%. Extensometric method was used to test the extensibility of the formulations. Potentiometric method was applied to measure the pH of the produced ointment. Viscosity parameters were determined with cone-plate digital rheometer. Pharmaceutical availability of substance was tested by spectrophotometric method. Result. The type of used vehicle has a significant effect on rheological parameters of tested ointments. The high perspiration number, high extensibility, low yield stress and low viscosity characterize preparations created out of a simple base ointment. The highest diffusion kinetics of morphine hydrochloride were observed at the ointments possessing the most beneficial properties, from the ointments made out of simple ointment. Key words: anhydrous absorptive ointments, morphine hydrochloride, propylene glycol, rheology, pharmaceutical avalilability |