Analysis of the composition of hybrid lacquers in terms of potentially allergic substancesAleksandra Swacha, Magdalena Niewęgłowska, Jadwiga Kalicińska Zakład Dermatologii Doświadczalnej i Kosmetologii, Uniwersytet Jagielloński Collegium Medicum Summary Introduction. Hybrid lacquers combines the traditional technology of nail polish with components curedwith UV/LED. The composition includes among others polymerization photoinitiatiors, methacrylate and acrylate oligomers or monomers. Despite the risk of side effects, hybrid nail styling is very popular. Aim. The aim of this study was to analyze the composition of hybrid lacquers intended for use on nails in terms of the presence of potentially allergenic substances. Material and methods. This analysis covered hybrid lacquers intended for use on nails produced by 15 cosmetic companies. Among them, 5 lacquers were distinguished: base, top and three colors. The products covered by the study were available at online drugstores, stationary in Krakow or on the manufactures´ websites. Identified ingredients were analyzed in the scientific literature for their sensitizing effects. The following bibliographic databases were used: MEDLINE - PubMed, Scopus and Embase. Results. The total number of individual ingredients declared by the manufactures of the tested hybrid lacquers were 176. Dyes constituted the most numerous group of ingredients - 53 (30%) dyes were identified out of 176 total substances. The analysis showed the presence of 2 dyes - CI 17200 (Acid Red 33) and CI 42510 (Fuchsine basic) which according to the Regulation of the European Parliament and of the Council (EC) No. 1223/2009 of 30 November 2009 are banned for use in cosmetics. Another large group of ingredients were acrylates - 36 (20.5%). The most numerous were: 2-HEMA (2-Hydroxyethyl Methacrylate) in 63 (84%) varnishes, while Di-HEMA TMHDC (Di-Hydroxyethyl Methacrylate Trimethylhexyl Dicarbamate) in 47 (62.7%). Conclusions. Potentially sensitizing substances are used in the production of hybrid lacquers. The most common substances from the group of acrylates with allergenic properties in the analyzed hybrid lacquers are 2-Hydroxyethyl Methacrylate (2-HEMA), 2-Hydroxypropyl Methacrylate (2-HPMA) and Ethylene glycol dimethylacrylate (EGDMA). From the group of dyes are CI 47000 (Quinoline Yellow) and CI 19140 (FD&C Yellow 5). The analysis showed the presence of dyes not allowed for use in cosmetics and those that should not be included in hybrid varnishes. Key words: hybrid varnishes, potentially sensitizing substances, acrylates, dyes |