search by
Copyright @ Pol J Cosmetol
Pol J Cosmetol 2024, 27(1): 31-36pl  Ideal and predicted actual solubility of resveratrol in ethanol solutions of variable polarityMarian M. Zgoda 1/, Sławomira Nowak 2/, Zbigniew Marczyński 3/, Zbigniew Binikowski 4/, Magdalena Markowicz-Piasecka 3/ 1/ Katedra Farmacji Stosowanej, Zakład Technologii Postaci Leku, Uniwersytetu Medycznego w Łodzi; profesor senior 2/ Katedra i Zakład Farmakognozji, Uniwersytetu Medycznego w Łodzi 3/ Katedra Farmacji Stosowanej, Zakład Farmacji Aptecznej, Uniwersytetu Medycznego w Łodzi 4/ Zakład Opiekuńczo-Leczniczy "Pod Dębami" w Łodzi Summary Introduction. Resveratrol - an ingredient of red wine, confirmed in clinical trials a wide range of biological activity, protecting humans against, among others, neurodegenerative and neoplastic diseases, as well as against heart and circulatory system diseases. Clinical studies have documented anti-inflammatory and antioxidant properties and inhibition of the oxidation process of LDL cholesterol. The available literature provides inspiration for calculating the expected solubility of resveratrol in aqueous ethanol solutions and in selected types of red wine. Aim. The aim was to estimate the thermodynamic parameters of resveratrol and, above all, to calculate the expected actual and ideal solubility in aqueous ethanol solutions and in selected types of red wine. The solubility parameter and solubility level of hydrophilic-lipophilic balance - were calculated for the isomeric structure of resveratrol. Material and methods. The ethanol content declared by the producers inspired the estimation based on the theory of ideal and expected solubility of resveratrol in aqueous ethanol solutions and types of red wine available on the Polish market. Results. It results from the calculated predicted actual and ideal solubility that an increase in the concentration of resveratrol is observed in up to 60% ethanol content in the aqueous solution, which is associated with a decrease in the polarity of the solution and regression of the solubility coefficient. The ethanol content declared by the manufacturer allowed to estimate the expected solubility (content) of resveratrol in selected types of red wine. Conclusions. The solubility parameter and polarity of its aqueous solutions calculated for the isomeric structure of resveratrol and aqueous ethanol solutions allowed to estimate the expected actual and ideal solubility in the potential process of effective extraction of material rich in phytochemicals. The general Hildebrand-Scatchard-Fedors solubility theory also makes it possible to estimate the potential concentration of resveratrol in red wine, basing on the ethanol content. Key words: resveratrol, ideal solubility, expected actual solubility, ethanol, solubility measurement, red wine |