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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2007, 10(2): 115-124pl,en  Aloe creams for dry skinTeresa Bujak, Marian M. Zgoda, Patrycja Jedlińska Katedra Farmacji Stosowanej, Uniwersytet Medyczny w Łodzi Summary Introduction. Aloe demonstrates multidirectional therapeutic activity conditioned by diverse chemical composition. Aloe extract has antibacterial, anti-inflammatory, regenerating and light-protective properties. It is one of the plants most frequently used in cosmetic creams for dry skin care. Aim. The aim of the study was to determine pharmaceutical availability of aloenin in freshly produced model creams containing aloe dry extract from fresh Aloe Arborescens Mill. leaves. Furthermore, the effect of urea on aloenin release from the tested model preparations was estimated. Material and methods. A technology of model aloe creams for dry skin has been worked out. An analysis of aloenin pharmaceutical availability in the tested creams was performed with a static method based on the dialysis of an active substance through semipermeable tomophan membrane in Mutimer apparatus. Direct spectrophotometric method was used to define active substances converted to aloenin Pharmaceutical availability of the tested creams was determined with biopharmaceutical parameters i.e. constant of release (k) and half time of release (t50%). Results. The results of the tests of aloenin content in the analysed material enable to include this compound to a group of compounds dominating in the chemical composition of Aloe Arborescens plants grown in greenhouses of herbal Works "Herbapol" S.A. in Klęka. On the basis of aloenin release from aloe creams, the usefulness of the suggested cream vehicles was also investigated. Conclusions. The selected tomophan dialysis membrane gave comparable results in the determinations of pharmaceutical availability and it is very useful in the testing of pharmaceutical availability of aloenin from the investigated creams. Urine did not affect the aloenin release from the tested model creams but according to the literature data it is a perfect moisturising agent advised for dry skin. Key words: Aloes, Aloe arborescens, aloe creams, moisturising creams, pharmaceutical availability, aloenin |