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Copyright @ Pol J Cosmetol
Pol J Cosmetol 2008, 11(3): 210-218pl,en  Macromolecular compounds of natural origin in the prescription of hydrogels with nonsteroidal anti-inflammatory drugsGrażyna Samczewska, Justyna Kołodziejska Katedra Farmacji Stosowanej Uniwersytetu Medycznego w Łodzi Summary Objective. The effect was assessed of selected macromolecular cross-linking substances of natural origin on morphological and rheological parameters of vehicles and hydrogel preparations produced according to own prescription and on pharmaceutical availability of nonsteroidal anti-inflammatory drugs (NSAIDs). Material and method. Hydrogen ions activity (pH) and pharmacopeal density (d) of vehicles and preparations produced according to own prescription were determined according to the guidelines of Polish Pharmacopoeia VI (PP VI). Flow curves, the value of structural viscosity and yield stress of vehicles and preparations were determined with cone-plate digital rheometer. Spectrophotometric method was used to test pharmaceutical availability of sodium ibuprofen and ketoprofen lysine from model hydrogels. Results. The value of pH of the preparations is within the limits: 6,16-7,87 and their density is close to 1. Ketoprofen lysine pharmaceutical availability from the tested hydrogels is higher than that of sodium ibuprofen. Low viscosity values are the base for anticipating high pharmaceutical availability of therapeutic agents from hydrogel with tragacanth. The area under the curve of ketoprofen lysine release from hydrogel with tragacanth was the highest (587,22 c.u.), whereas for the other model preparations the values not higher than 457,80 c.u. were obtained. Conclusions. Ketoprofen lysine releases best from the tragacanth cross-linked preparation which has the lowest value of structural viscosity and yield stress. Key words: hydrogels, polysaccharides, nonsteroidal non-inflammatory drugs, pharmaceutical availability |