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Pol J Cosmetol 2008, 11(4): 295-306pl,en  Comparison of rheological parameters and pharmaceutical availability of morphine hydrochloride and morphine sulphate with ointments disposed on wounds and ulcersGrażyna Samczewska Katedra Farmacji Stosowanej Uniwersytetu Medycznego w Łodzi Summary Introduction. The discovery of opioid receptors in peripheral tissues initiated local application of morphine on painful deep wounds i.e. on neoplastic skin ulcerations and decubitus ulcers. In such pathologies not only drug analgesic activity is of importance but also disinfecting activity and facilitating wound healing. Balsam of Peru (Balsamum peruvianum) demonstrates them. Aim. Ointments - emulsion w/o eucerine base were subject of investigations. The ointments had in their composition morphine hydrochloride or sulphate and balsam of Peru. Pharmaceutical availability of morphine salt from the produced preparations was tested spectrophotometrically. Rheological parameters of the ointment and hydrogen ions activity (pH) were also measured. Material and method. On eucerine base ointments were produced with balsam of Peru and together with balsam and morphine hydrochloride or sulphate. Potentiometric method was applied to measure pH of the produced ointments. Extensometric method was used to test spreadability of the preparations. Viscosity parameters were tested with the cone-plate rheometer. The test for morphine hydrochloride (MCl) and morphine sulphate (MS) farmaceutical availability was performed with spectrophotometric method. Results and discussion. The ointments with balsam of Peru and with balsam and morphine hydrochloride or sulphate are not compatible with skin (pH<4). Extensibility of the ointment with balsam of Peru and morphine salt is lower than extensibility of the vehicle and ointments containing only balsam of Peru. The balsam of Peru contributed to the increase of the ointment viscosity, whereas aqueous solutions of morphine salts to its decrease. All the tested ointments are viscoelastic having experimentally determined yield stress. Pharmaceutical availability of morphine salt was the highest with 5% contents of balsam of Peru. Conclusions. The percentage contents of balsam of Peru affects significantly the pharmaceutical availability of morphine salt from the tested ointments. Key words: morphine, Peru balsam, ointment, pharmaceutical availability, rheological parameters |