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Pol J Cosmetol 2013, 16(4): 300-305pl  Aloe ointments with Scutellaria baicalensisTeresa Bujak Katedra Farmacji Stosowanej, Uniwersytet Medyczny w Łodzi Summary Introduction. Aloe extract has antibacterial, anti-inflammatory, regenerating and light-protective properties and 5% ointments can be applied in the treatment of dermatomycoses. Raw material of Chinese origin, root of Scutellaria (Radix Scutellariae), is a source of typical flavone compounds, mainly lipophilic flavones. Baicalin and its derivatives: baicalein and wogonin are the major yellow flavonoid pigments. Aim. The aim of the study was to determine the pharmaceutical availability of aloenin in freshly made antifungal ointments containing aloe dry leaf extract from fresh Aloe Arborescens Mill. Whereas, the calibration curve, determining the correlation between absorbance and the substance concentration, was established for Scutellaria baicalensis. The concentration of baicalin released from model ointments containing dry extract from Radix Scutellariae was determined on the basis of the established calibration curve. Material and methods. The technology of a few antifungal ointments with aloe and scullcaps has been worked out. The analysis of aloenin pharmaceutical availability in ointments was carried out with the static method based on the dialysis of an active substance through Tomophan-type selectively semipermeable membrane in Mutimer apparatus. Direct spectrophotometric method was used in the chemical analysis to determine active substances converted to aloenin. Pharmaceutical availability of the tested ointments was determined with biopharmaceutical parameters i.e. constant of release rate (k) and half-time of release (t50%). The concentration of baicalin released from the model ointments was determined on the basis of the established calibration curve. Results. The results of the tests of aloenin content in the analyzed material allow to include this compound to the group of compounds dominating in the chemical composition of Aloe Arborescens plants grown in greenhouses of Herbal Works ´Herbapol´ S.A. in Klęka. Moreover, the usefulness of the suggested ointment vehicles was tested on the basis of aloenin and baicalin release from the model ointments. Conclusions. The selected Tomophan-type membrane gave comparable results in the determinations of pharmaceutical availability and it is very useful in the investigations of aloenin pharmaceutical availability from an ointment and in the determination of the concentration of baicalin released from the model ointments. Propylene glycol is a good promoter of aloenin and baicalin release from model ointments. Key words: Aloe, Aloe arborescens, aloe ointments, pharmaceutical availability, aloenin, Radix scutellariae, ointments with Scutellaria baicalensis |