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Pol J Cosmetol 2008, 11(1): 56-63pl,en  Dental anti-inflammatory hydrogels with ketoprophene, brine and zinc chloride. Part II. Testing the hydrogel durabilityJustyna Kołodziejska Katedra Farmacji Stosowanej Uniwersytetu Medycznego w Łodzi Summary Aim. An attempt was made to estimate the durability of dental anti-inflammatory hydrogels with ketoprofen, brine and zinc chloride, which were produced on variant vehicles. Material and method. Hydrogel samples were closed in polypropylene tubes and stored in an incubator at 37±0,1°C with gravitational air circulation for 3 months. After 3 months of storage, the hydrogel pH (aH+) was determined with potentiometric method, the kinetics was tested of ketoprofen release from the produced systems and rheological measurements (cone-plate rheometer) were performed. The obtained values were compared with the results obtained ex tempore. Results and discussion. After 3 months of storage at 37±0,1°C, hydrogels with Carbopol Ultrez 10 and Carbopol 980 demonstrated the most similar ph (5,73-5,96) to ketoprofen pKa (5,94). The areas under the curves of therapeutic agent release from these hydrogels were the highest: 109,96-175,93 c.u. The process of ketoprofen release from all the produced preparations was in accordance with the kinetics of "0" order. The progression of ketoprofen pharmaceutical availability after 3 months of storage concerned hydrogels the viscosity of which decreased. Conclusions. The most beneficial results were obtained for hydrogels with Carbopols. They are hydrogels demonstrating very high pharmaceutical availability of ketoprofen, appropriate viscosity parameters and structure stability after 3-month storage period. Key words: inflammatory states, hydrogels, ketoprofen, zinc chloride, pharmaceutical availability, durability tests |